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Q &y#:T ;- |'b_j2KhW_ \Ǒ ;k_u~j =ˡvPK߶?(+(w37<Dފ;p?XevhZ^ӕf4Zk sXaFsW'Wr.K Ҁ}vysqᇺeAQD𡛻RX٦>* /~}Az_d=xi endstream endobj 47 0 obj <>stream hތW]h\ERZ"qHݝ;j) -ҰdWۘ[mvMqItS"ZeAh|P,5X)hٟ̽;9sow,1s/c Lw0O1Sca&]r=5.K.S}{y{s QQ9D-@Pp\A$HMmz~ kzV{^hr&֠>lƩ*LBiHN3U ̪ WԢy1p>EP FO^kެ_ Zɩ#ԍ6f6\,! soCB_,.4]A\SL>GD%*#:@4@pD/RTP;}r{;4*( Y]{%A#2[m\ɬ~PaHM$#2[7k !#96bmh/hnL`Gfb<)= l* h<ՙ03>BF]BfP%MJE29rhJN -̬5B(* (VP'vP}.  Ml8 j#%t(S,O@+nVG F~aHiЮU5+i4洗YCqiƪ ǭJ*̂! ;.nF]pi&s]p)=qv/nN\ryμ w{ .˳Jަp{VEo"f&*x;v'TU#X55#XJC"^.s6#"]3&ύxh&=d|q`{/8$r]#7fY/5G[_?(z2Lond7՜3Xz)x+'vzWJxZ=pHf9dBD`f0 endstream endobj 48 0 obj <>stream 2024-04-16T11:27:21+08:00 2024-04-16T11:27:19+08:00 2024-04-16T11:27:21+08:00 Acrobat PDFMaker 11 Word 版 uuid:e560697c-582d-4a6d-b208-033b980c5e1d uuid:be4b940e-9bbd-4be4-9b02-2d4a1014b939 487 application/pdf 氨基酸转运体SLC1家族作为肿瘤治疗靶点的研究进展 目的:整理综述氨基酸转运体SLC1家族的生理特性以及目前作为肿瘤治疗靶点方面的研究进展。方法:通过查找中国知网、PubMed等文献数据库,整理国内外有关SLC1家族生理特性以及影响肿瘤代谢的研究报告,整理出SLC1家族在靶向治疗肿瘤领域的相关研究进展。结果:SLC1家族成员在肿瘤代谢过程中可通过促进细胞内外谷氨酸合成谷胱甘肽、通过谷氨酰胺摄取和mTOR信号传导实现谷氨酰胺的过度表达、通过调节R-2-羟基戊二酸癌代谢物(R-2-HG)、HIF-1α以及p13K/AKT通路等促进肿瘤细胞的发展,除此之外,很多研究中也发现SLC1家族成员与肿瘤细胞的自噬和凋亡、氧化应激反应、细胞有丝分裂以及癌基因的表达等多种因素相关,靶向SLC1家族的抗肿瘤药物已成为目前肿瘤药物研究的热点。结论:本文通过大量文献综述,系统地整理总结四种SLC1家族成员与不同肿瘤细胞之间的影响机制研究进展,但目前多种氨基酸转运体在肿瘤细胞中的作用机制仍不够明确,在今后的研究中进一步探究SLC1家族成员抗肿瘤治疗的作用机制。 吴红霖, 罗鹏飞, 晏玲英, 安静, 彭小珍 Adobe PDF Library 11.0 溶质载体家族1,肿瘤细胞,氨基酸转运体,靶向治疗 D:20240416032707 çł®çı—ï¼ıæŁ´ç’ƒç»¼è¿°æ°¨å�ºé–¸è½¬è¿’ä½fiSLC1家抑çı—çfl�璃盹敧以å‘−çł®å›“ä½œä¸ºè‡¿çŸ¤æ²»çŒŠéš¶ç‡¹æŒ¹éš¢çı—ç€flç©¶è¿łå±Łã•‡æŒ¹æ³Łï¼ıé•ıè¿⁄æ�¥æ›¾ä¸�åł½ç�¥ç½‚㕆PubMedç�›æŒ⁄ç„®æŁ°æ“®åºfiï¼„æŁ´ç’ƒåł½åƒ–å¤Œæœ›å–³SLC1家抑çfl�璃盹敧以å‘−å½±åfi“臿矤代谢çı—ç€fl究æ−¥å‚−ï¼„æŁ´ç’ƒå⁄ºSLC1家抑在隶咂治猊臿矤颃å��çı—çł¸å–³ç€flç©¶è¿łå±Łã•‡ç»fiæžœï¼ıSLC1家抑拒傟在臿矤代谢è¿⁄稉ä¸�呯é•ıè¿⁄ä¿…è¿łç»ƒè…žåƒ–å¤Œè°·æ°¨é–¸å’‹æ‹’è°·è…±çflŸè‡½ã•†é•ıè¿⁄谷氨閰腺悗呌噄mTOR信呷伀导实田谷氨閰腺çı—è¿⁄度表达㕆é•ıè¿⁄è°…è−‡R-2-ç¾�å�ºæ‹−亄閸玄代谢盩(R-2-HG)㕆HIF-1α以å‘−p13K/AKTé•ıè·¯ç�›ä¿…è¿łè‡¿çŸ¤ç»ƒè…žçı—å‘‚å±Łï¼„éŽ¤æ�¤ä¹‰å¤Œï¼„律å¤ıç€fl究ä¸�ä¹�å‘‚ç”°SLC1家抑拒傟且臿矤练腞çı—è⁄ªåŽ¬å™„å⁄‰äº¡ã•†æ°§å„Œåºflæ¿•å‘“åºfl㕆练腞望业勃裇以å‘−玄å�ºåł€çı—表达ç�›å¤ıç§“åł€ç´€çł¸å–³ï¼„éš¶å’‚SLC1家抑çı—æ−Šè‡¿çŸ¤è“¯ç›©å·²æ‹’ä¸ºçł®å›“è‡¿çŸ¤è“¯ç›©ç€fl究çı—ç…�燹㕇ç»fi论ï¼ı本æŒ⁄é•ıè¿⁄大é⁄‘æŒ⁄焮综述$系ç»�åœ°æŁ´ç’ƒæ•»ç»fiåłłç§“SLC1家抑拒傟且专咄臿矤练腞义銴çı—å½±åfi“机勶ç€flç©¶è¿łå±Łï¼„ä½ƒçł®å›“å¤ı秓氨å�ºé–¸è½¬è¿’ä½fi在臿矤练腞ä¸�çı—作çfl¨æœºå‹¶ä»“专å¤�柔确$在ä»−å’”çı—ç€fl究ä¸�è¿łä¸•æ�¥æ”¢ç©¶SLC1家抑拒傟æ−Šè‡¿çŸ¤æ²»çŒŠçı—作çfl¨æœºå‹¶ã•‡ endstream endobj 49 0 obj <>stream h20W0Pw/+QL)64)@H B)#e %,HHLO-0*9 endstream endobj 50 0 obj <>stream htSahe~Aq RF@v.-KcPjkܙzk]4/ɷuiq+N2q~ :q 0?m"#9y~_tS}w> 0,sg(;ο-t {Yܤ>{a=MS$=>/Filter/FlateDecode/ID[<6C7CA2EC703DDD41B56E19AE19F15304>]/Info 388 0 R/Length 238/Root 390 0 R/Size 389/Type/XRef/W[1 3 1]>>stream hbb&F]} Rj.d9  V R^H24E<@7"5: "%@$XDEE