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rB/Y3}z&G0v:d)'ᅩv݇F餛!=f=ZhZ|',~?ģO#)Dhϓ}1XB o%D&Xi3-̈yrѷJJ0bD%yĠKafdfl!d>\gIf>f93ihj˥Z.@L|tw.Eh|bi(ByZPJ+=wq$ᣨ8i74e4FFрc` dޅxRP ZN0;cSaٱR"G)р {k>?Y}0uY{/&&='lݗ컩а¾CAV[D!6 z!򻅞!Hʿ<oos94?(Ms4fPG :_?RB3)!oW[*X߃Tԣ7ZWߠG{^_/:zt/tFP6"6Ezח\WKw\]>ם=v;7w{r:s9&LdW(CH\HqA9M۵:^XǾJug{[Y3XWGuMUɅẴ+Ӑ%] c{J3jYFd힞-c.ݏ77S~JEwUϖ~ɽu@s2"L.T.>Į˫_jiKٵ "_[Z\fka\v0<+Ҧ(R\c 6TEF^ Kɮ]FlQߠOl*隧+ sƗ*:b8av̽paF~})87SrJE.CˇCK3;ӔLgEvuVȈ3h }M"hD>< Kd]#kIV0i%.ctcO ?6z,>ե ](/E"B#܎ڶ$>stream hޤVn@}lm)B"$TMBcZ`%_"Q7ή!4!lgvdzsY|$@* P;YN B)0-yrD=C`H05"*t/KKwó$Slnf3yQvQWμ,7e=tE1\=j<ُ̟@::;y]#3/ńxm/ƴ݆b;L%E6eϱFZ ܋Ew)/.Iw*%̞P/JL]rXSeYmFk;,s]Ζ6˓(vQU Kt*n'F{ -@ 1b[7;rΝeTk6wz7'ܹoVW8k&e5Mӝ֒=Iw1D(& ڡ^ [ԅ?>O-؝*+z\yٽu@U+,H)-/sh)W뚠=QAE! sVA:? >stream hބUkAPz$ .BUPIbnC!MJv[A4Xzx<УxJ{l2Lay;;}{߼7˸Ox@̅WQrRU`u=GdX* 0.>,P_@`4`h( x# `P!1ȄU!<%K&C >{"K8B$wLþ (grlΰ\+1d.mԢX|Z03]0\Tq1S6rxan\"Y2IxXlsAnk~N/Z=bƹ NB0S DM§'q:n/,^~^.2skӮ&RlDQB[o[|v>|RZnbJͯWIJN-#L:/E[420dʛ+guNM96vҪ#$.&mQXO:[RVcW@(C@H P;8gܩ}["#KZe9*-ϣe V+שN :T'Q]{у}\TDnBx2TC4iw~)z̪Ӣ$$;6Y#T: a}s>YB"eJ9 E} `RI',)A*)v llA"R%zl0M)nǭ<1lG 2^U` XׂBMX]VHڽ;)ϔFŜO1dz>g磭\i?i6r TH<@'Kܸ|0t*!n^/w/GJ{浖UAy⓾cIlV{A 0A) endstream endobj 40 0 obj <>stream 2023-05-31T09:25:50+08:00 2023-05-31T09:25:48+08:00 2023-05-31T09:25:50+08:00 Acrobat PDFMaker 11 Word 版 uuid:0312aa5f-2a1e-43fd-84bd-810abcc5aecc uuid:6438eb5d-9c58-4912-aa2d-4658c1e35fd1 24 application/pdf 基于FAERS的曲美替尼相关神经系统不良事件信号挖掘研究 目的:基于FAERS对曲美替尼(TRA)相关神经系统不良事件(ADE)进行信号挖掘,探索ADE的发生特点,TRA与ADE的相关性及TRA发生神经系统相关ADE的高危因素,期望为临床安全应用TRA提供参考。方法:提取FAERS 2017年第一季度至2022年第四季度共24个季度的TRA相关神经系统ADE报告数据,利用报告比值比(ROR)法和综合标准(MHRA)法进行数据分析。结果共获得TRA报告数4392个,其中TRA相关神经系统ADE报告数86个,有信号的PT共15个,可分为7个高危组语(HLGT)。报告数居前3位的PT依次是惊厥发作、晕厥、困倦;信号强度居前3位的PT依次为中枢神经系统疾病、轻偏瘫、脑积水。药品说明书中未收录的PT有15个。结论:需重视TRA相关神经系统不良事件的风险,尤其是外周神经系统和脑积水,有神经系统相关基础疾病的患者需加强监护,保障用药安全。 黄开洋, 杨果, 丁艳, 黎丹 Adobe PDF Library 11.0 曲美替尼,神经系统,FAERS D:20230531012531 çł®çı—ï¼ıå�ºäº”FAERSå¯¹æł²ç¾”æł¿å°¼(TRA)çł¸å–³ç¥žç»‘ç³»ç»�专蛯争件(ADE)è¿łè¡„ä¿¡å‘·æ„Œæ”Ÿï¼„æ”¢ç´¢ADEçı—å‘‚çfl�盹燹$TRA且ADEçı—çł¸å–³æ•§å‘−TRAå‘‚çfl�神绑系ç»�çł¸å–³ADEçı—é«Ÿå“±åł€ç´€ï¼„æœ�æœłä¸ºä¸´åº−宛喨åºflçfl¨TRAæ‘’ä¾łå‘‡è•…ã•‡æŒ¹æ³Łï¼ıæ‘’å‘ŒFAERS 2017年第丕å�£åº¦è⁄³2022å¹´ç¬¬åłłå�£åº¦å–±24个å�£åº¦çı—TRAçł¸å–³ç¥žç»‘ç³»ç»�ADEæ−¥å‚−æŁ°æ“®ï¼„å‹©çfl¨æ−¥å‚−æ¯fl啼æ¯fl(ROR)æ³Łå™„ç»¼å’‹æ€⁄å⁄ƒ(MHRA)æ³Łè¿łè¡„æŁ°æ“®å‹ƒæž’ã•‡ç»fi果喱蔷徊TRAæ−¥å‚−æŁ°4392个$営ä¸�TRAçł¸å–³ç¥žç»‘ç³»ç»�ADEæ−¥å‚−æŁ°86个$望信呷çı—PTå–±15个,呯勃为7个髟哱绗è¯�(HLGT)㕇æ−¥å‚−æŁ°å±–å›“3体çı—PT侚次柯æ…−å”¥å‘‚ä½œã•†æŽŁå”¥ã•†åł°å•¦ï¼łä¿¡å‘·å¼ºåº¦å±–å›“3体çı—PT侚次为ä¸�枢神绑系ç»�猾犖㕆轻冑矫㕆藂积水㕇蓯åfi†è¯´æŸ”书ä¸�未æfl¶å½Łçı—PT望15个㕇ç»fi论ï¼ı霕é⁄“觃TRAçł¸å–³ç¥žç»‘ç³»ç»�专蛯争件çı—飔鎩$尤営柯夌储神绑系ç»�噄藂积水$望神绑系ç»�çł¸å–³å�ºç¡•çŒ¾çŠ–çı—懣蕖霕å−€å¼ºçł‚æ−¤ï¼„ä¿šéıœçfl¨è“¯å®›å–¨ã•‡ endstream endobj 41 0 obj <>stream h243V0Pw/+Q0L)643)I "ddXʂTb;;oY endstream endobj 42 0 obj <>stream h|S[OA>\nE;-!F@tzbشRYXU }P1^#F `xqa-b$f;;|3UaSWiٔ#Qػ *S0]H]GZֹMɟ*Ųi>^7rWJuWyj6rf"@bP'yh%MsۧB|d:Öa +yTY1AUIh} %.1F9Wcjq6!)*J'LKD.7#YFo m_g5`| POQ1# ğ(G*@m>%y&^]k7Vs]$6衤=NqSD]xue Z.^o;JEjEEvd3F{'%7 җ͑ mbd|7>/Filter/FlateDecode/ID[<97911A60E420144BADAD2ED25FDF3CC7><75885701BFCD3749B8AAD034196B49BC>]/Info 164 0 R/Length 204/Root 166 0 R/Size 165/Type/XRef/W[1 3 1]>>stream hbb&FV&ƽ Rj:d=  V R^DE*H$) "*"Q 5X XW/XD w4 hb0_D2{E 7\ ,Og/G!-D69,?" #9Fd 9mje c$= ,w endstream endobj startxref 116 %%EOF