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Q"У,lÔt\7w-^(G: fO~ endstream endobj 27 0 obj <>stream 2014-12-30T18:12:45+08:00 2014-12-30T18:12:43+08:00 2014-12-30T18:12:45+08:00 Acrobat PDFMaker 11 Word 版 uuid:adf15b5e-40de-4346-92a9-980859f3dd78 uuid:6e0bf176-a81a-41d1-b15a-5dd6970e465b 100 application/pdf 卡培他滨单药或联合方案治疗转移性乳腺癌临床疗效观察 目的:观察卡培他滨单药或联合方案治疗蒽环及紫衫类化疗后转移的乳腺癌的临床疗效及毒副反应。方法:2007年7月~2014年6月贵州省肿瘤医院乳腺、妇科肿瘤科收治转移性乳腺癌20例,其中:锁骨上淋巴结转移4例,肺转移5例,骨转移4例,肝转移1例,脑转移1例,皮肤转移1例,对侧乳腺转移1例,多脏器转移3例。全组病例均行蒽环类或/和紫杉类药物辅助化疗。全组病例给予含卡培他滨单药或联合方案化疗。治疗前中位KPS评分90分。其中单药治疗2例;卡培他滨连用曲妥珠单抗2例;联合贝伐单抗1例;联合吉西他滨9例;联合顺铂1例;联合紫杉醇2例;联合多西紫杉醇3例;化疗周期数2~6周期,中位周期数:4周期。所有病例治疗后均根据RECIST实体瘤客观评价标准(1.0版)进行疗效评价,毒副反应按WHO抗癌药物毒副反应评价标准进行评价。结果:其中有1例因失访后未能进行疗效评价。可评价例数共19例,其中1例达CR;6例达PR;6例达SD;6例达PD,有效率为36.8% (7/19)。治疗后出现转移的时间为2~33月,中位无疾病进展时间(PFS)为13月。20例患者出现1例4度骨髓抑制,1例3级吐消化道反应,经对症治疗后好转,其余1~2级消化道反应患者均能承受。出现4例1~2级手足综合症。结论:以卡培他滨单药或联合方案对既往紫衫、蒽环类化疗失败的转移性乳腺癌患者有一定疗效,且不良反应可以耐受,可作为转移性乳腺期有效治疗方案。 李杰,李凤虎,常建英,李杰慧,袁佳,刘诗苑,冉立 Adobe PDF Library 11.0 转移性乳腺癌,卡培他滨,临床疗效,毒副反应,无疾病进展时间 D:20141230101237 çł®çı—ï¼ı觇å¯�å“¡å�¹ä»Œæ»¨å“Łè“¯æ‹Œè†fl咋挹桋治猊虽甯å‘−紫衫类儌猊咔转移çı—乳薺玄çı—临åº−çŒŠæŁ‹å‘−毙囯呓åºflã•‡æŒ¹æ³Łï¼ı2007å¹´7朋~2014å¹´6朋贵州眆臿矤儻鎢乳薺㕆å¦⁄秂臿矤秂æfl¶æ²»è½¬ç§»æ•§ä¹³è–ºçŽ„20侉$営ä¸�ï¼ıéfl†éª¨ä¸−淉巴ç»fi转移4侉$臺转移5侉$骨转移4侉$臚转移1侉$藂转移1侉$çı®è‡¤è½¬ç§»1侉$对侧乳薺转移1侉$å¤ı藑厨转移3侉㕇喨绗犖侉åš⁄衄虽甯类拌/噄紫暛类蓯盩辖å−©å„ŒçŒŠã•‡å–¨ç»—犖侉绎事咫員å�¹ä»Œæ»¨å“Łè“¯æ‹Œè†fl咋挹桋儌猊㕇治猊囓ä¸�体KPS诗勃90勃㕇営ä¸�å“Łè“¯æ²»çŒŠ2ä¾‰ï¼łå“¡å�¹ä»Œæ»¨è¿žçfl¨æł²å¦¥ç‘€å“Łæ−Š2ä¾‰ï¼łè†flå’‹è´šä¼’å“Łæ−Š1ä¾‰ï¼łè†fl咋咛西仌滨9ä¾‰ï¼łè†fl咋顺éfi‡1ä¾‰ï¼łè†flå’‹ç´«æš›éƒ⁄2ä¾‰ï¼łè†flå’‹å¤ı西紫暛éƒ⁄3ä¾‰ï¼łå„ŒçŒŠå‚¨æœ�æŁ°2~6储æœ�$ä¸�体储æœ�æŁ°ï¼ı4储æœ�㕇曕望犖侉治猊咔åš⁄怹擮RECIST实ä½fi矤客觇诗价æ€⁄å⁄ƒ(1.0盋)è¿łè¡„çŒŠæŁ‹è¯—ä»·ï¼„æ¯™å›¯å‘“åºflæ„›WHOæ−ŠçŽ„蓯盩毙囯呓åºfl诗价æ€⁄å⁄ƒè¿łè¡„诗价㕇ç»fiæžœï¼ıå–¶ä¸�望1ä¾‰åł€å¤±è®¿å’”æœªè…½è¿łè¡„çŒŠæŁ‹è¯—ä»·ã•‡å‘¯è¯—ä»·ä¾‰æŁ°å–±19侉$営ä¸�1侉达CRï¼ł6侉达PRï¼ł6侉达SDï¼ł6侉达PDï¼„æœ›æŁ‹ç”⁄为36.8% (7/19)㕇治猊咔å⁄ºç”°è½¬ç§»çı—抶銴为2~33朋$ä¸�ä½“æŠ€çŒ¾çŠ–è¿łå±ŁæŠ¶éŠ´(PFS)为13朋㕇20侉懣蕖å⁄ºç”°1侉4度骨é«fiæ−‚勶$1侉3级咒涋儌é†fiå‘“åºfl$绑对çŠ⁄治猊咔好转$営低1~2级涋儌é†fiå‘“åºfl懣蕖åš⁄腽替告㕇å⁄ºç”°4侉1~2级曉足综咋çŠ⁄㕇ç»fi论ï¼ı以員å�¹ä»Œæ»¨å“Łè“¯æ‹Œè†fl咋挹桋对抢徕紫衫㕆虽甯类儌猊失败çı—转移敧乳薺玄懣蕖望丕å®ıçŒŠæŁ‹ï¼„ä¸fl专蛯呓åºfl呯以蕒告$呯作为转移敧乳薺æœ�æœ›æŁ‹æ²»çŒŠæŒ¹æ¡‹ã•‡ endstream endobj 28 0 obj <>stream h24T0Pw/+Q0L)646)IKB)#RYZlg`M endstream endobj 29 0 obj <>stream htThu 8Hk)!M,[45]r%HӮX`R? 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