Abstract: This article proposed a real-time measurement method based on monocular vision system to measure the pose parameters of aerospace simulator. Several feature points were arranged on the surface of aerospace simulator and monocular camera was used to extract the images of feature points. Monocular vision coordinates measurement model and pose computation model were established to obtain the pose parameters of aerospace simulation. Finally, experiments were conducted to verify the feasibilities of applying monocular-vision method to measure the pose of aerospace simulator.