摘要:目的：研究心脑佳配方对慢性酒精中毒大鼠学习记忆及前额叶皮质丝切蛋白含量的影响。方法：建立大鼠慢性酒精中毒模型、Y-迷宫实验探究心脑佳配方对学习记忆的影响、免疫组化检测皮质额叶丝切蛋白含量。结果：学习记忆测试显示对照组大鼠学习记忆成绩比酒精中毒模型组明显升高(P < 0.01)，心脑佳配方组与酒精中毒模型组相比，学习记忆成绩明显上升(P < 0.01)；对照组大鼠前额叶皮质中丝切蛋白含量较酒精中毒模型组明显升高(P < 0.01)，而心脑佳配方组与模型组相比，前额叶皮质中丝切蛋白含量明显增加(P < 0.05)。结论：心脑佳配方可通过增加前额叶皮质中丝切蛋白含量、提升学习记忆能力。

Abstract:Objective: To study the effect of xin nao jia formula on the learning and memory abilities and cofilin content of prefrontal cortex in the chronic alcoholism rats. Methods: Establish chronic alcoholism rat model; use Y-maze experiment to explore the learning and memory abilities of xin nao jia formula and immunohistochemical experiment to detect the cofilin content in prefrontal cortex. Results: Learning and memory tests showed that the learning and memory scores of control group rats have significantly increased more than the alcohol poisoned model group (P < 0.01), and xin nao jia formula group increased obviously more than alcohol poisoned model group, (P < 0.01). The cofilin content of prefrontal cortex of control group rats significantly increased more than alcohol poisoned model group (P < 0.01), and xin nao jia formula group increased obviously more than alcohol poisoned model group (P < 0.05). Conclusion: Xin nao jia formula can promote learning and memory abilities by adding cofilin content in the prefrontal cortex abilities.