基本情况
山东大学微生物技术国家重点实验室,教授,博士生导师。滨州魏桥国科高等技术研究院,高级研究员。
研究领域
微生物合成生物学及生物制造。
教育背景
1993-1998 博士,山东大学-大阪大学中日联合培养
1988-1991 硕士,山东大学
1984-1988 学士,山东大学
工作经历
2024-08-至今 滨州魏桥国科高等技术研究院,高级研究员
2002-2024 教授,博导,山东大学
1999-2002 副教授,山东大学
1993-1999 讲师,山东大学
1991-1993 助教,山东大学
科研项目
1. 魏桥国科高等技术研究院项目,合成生物学平台建设及产品研发,2024-2029,主持
2. 国家重点研发项目子课题,2022YFC3401702,高效合成UDP-葡萄糖的糖基转移酶的挖掘与改造,2022年11月-2027年10月,主持
3. 国家自然科学基金面上项目,31570036,喜温硫杆菌(Acidithiobacillus caldus)胞内硫代谢基础研究,2016年01月-2019年12月,主持
4. 国家自然科学基金面上项目,31370138,喜温硫杆菌硫代谢双组份调节系统基础研究,2014年01月-2017年12月,主持
5. 国家自然科学基金面上项目,31070034,喜温硫杆菌SOX硫氧化系统机制及分子改造,2011年01月-2013年12月,主持
6. 国家863项目,2007AA05Z455,高活性木质纤维素降解专用复合酶制剂的制备技术,2007年12月至2010年11月,主持
7. 国家科技支撑专题项目,2011BAC02B04,菊芋高值利用及清洁生产技术示范,2011年01月-2014年12月,主持
论文发表
1. Wen X, Lin H, Tesfay MA, Ning Y, Liu G, Ren Y, Zhang C, Lin J *, Lin J *. Bioproduction of high-allulose-fructose syrup from d-glucose catalyzed by recombinant E. coli co-expressing glucose isomerase and D-allulose 3-epimerase. Food Bioscience 2023, 56, 103222.
2. Shi Y, Wu W, Yang Y, Liu X, Lin J, Liu X, Lin J*, Pang X*, Gene knockout of glutathione reductase results in increased sensitivity to heavy metals in Acidithiobacillus caldus, Frontiers in Microbiology, 10.3389/fmicb.2023.1250330
3. 温鑫,刘光文,宁宇航,Tesfay MA,林建强,任一林,林慧彬,宋欣,林建群. D-塔格糖生物合成 研究进展,食品与发酵工业,2023(网络首发)《食品工业与发酵》微信公众号论文荐读
4. Chen LF, Chen LX, Pan D, Ren Y, ZhangJ, Zhou B, Lin J*, Lin J,Ammonium removal characteristics of Delftia tsuruhatensis SDU2 with potential application in ammonium‑rich wastewater treatment, Int. J. Environ. Sci. Technol., 2023, 20:3911–3926,https://doi.org/10.1007/s13762-022-04219-3
5. Wen X, Ning Y, Lin H, Ren Y, Li C, Liu Y, Zhang C, Lin J*, Lin J*, D-Allulose (D-psicose) biotransformation from D-glucose, separation by simulated moving bed chromatography (SMBC) and purification by crystallization, 2022, Process Biochemistry, https://doi.org/10.1016/j.procbio.2022.05.013
6. Wen X, Lin H, Ning Y, Liu G, Ren Y, Li C, Zhang C, Lin J*, Song X*, Lin J, D-Allulose (D-psicose) biotransformation from allitol by a newly founded NAD(P)-dependent alcohol dehydrogenase from Gluconobacter frateurii NBRC 3264 and the enzyme characterization, 2022, Frontiers in Microbiology, https://doi: 10.3389/fmicb.2022.870168
7. Wen X, Lin H, Ren Y, Li C, Zhang C, Lin J, Lin J*, Allitol bioproduction by recombinant Escherichia coli with NADH,regeneration system co-expressing ribitol dehydrogenase (RDH) and formate dehydrogenase (FDH) in individual or in fusion, 2022, Electro J Biotechnol, 55: 91–98.
8. Tesfay MA, Wen X, Lin H, Liu Y, Li C, Lin J*, Lin J, Efficient L-xylulose production using whole-cell biocatalyst with NAD+ regeneration system through co-expression of xylitol dehydrogenase and NADH oxidase in Escherichia coli, Biochem Eng J, 2021, 175:108173. https://doi.org/10.1016/j.bej. 2021.108137
9. Tesfay MA, Wen X, Liu Y, Lin H, Chen L, Lin J*, Lin J, Construction of recombinant Escherichia coli expressing xylitol‑4‑dehydrogenase and optimization for enhanced L‑xylulose biotransformation from xylitol, Bioprocess and Biosystems Engineering, 2021, https://doi.org/10.1007/s00449-020-02505-3
10. Chen L,Chen L, Pan D, Lin H, Yilin Ren Y, Zhang J, Zhou B, Lin J, Lin J, Heterotrophic nitrification and related functional gene expression characteristics of Alcaligenes faecalis SDU20 with the potential use in swine wastewater treatment. Bioprocess and Biosystems Engineering,12 May, 2021, https://doi.org/10.1007/s00449-021-02581-z
11. Wen X, Lin H, Ren Y, Li C, Zhang C, Song X*, Lin J, Lin J*, Optimization for allitol production from D-glucose by using immobilized glucose isomerase and ecombinant E. coli expressing D-psicose-3-epimerase, ribitol dehydrogenase and formate dehydrogenase, Biotechnol Lett, 2020, https://doi.org/10.1007/s10529-020-02917-x
12. Wen X, Lin H, Ren Y, Li C, Zhang C, Song X*, Lin J, Lin J*, Efficient allitol bioproduction from D-fructose catalyzed by recombinant E. coli whole cells, and the condition optimization, product purification, Applied Biochemistry and Biotechnology, 2020, https://doi.org/10.1007/s12010-020-03359-x
13. Gao X, Fu C, Hao L, Gu X, Wang R, Lin J, Liu X, Pang X, Cheng-Jia Zhang, Lin J* Chen L*. The substrate-dependent regulatory effects of the AfeI/R system in Acidithiobacillus ferrooxidans reveals the novel regulation strategy of quorum sensing in acidophiles. Environ Microbiol, 2020, doi: 10.1111/1462-2920.15163.
14. Chen X, Li X, Ha Y, Lin J; Liu X, Pang X, Lin J*, Chen L*. Ferric uptake regulator provides a new strategy for acidophile adaptation to acidic ecosystems, Appl Environ Microbiol, 2020, 86(11): e268-20.
15. Li M, Gao X, Li C, Yang C, Fu C, Liu J, Wang R, Chen L, Lin J, Liu X, Lin J*, Pang X*. Isolation and identification of chromium reducing Bacillus cereus species from chromium-contaminated soil for the biological detoxification of chromium. International Journal of Environmental Research and Public Health. 2020. doi:10.3390/ijerph17062118