诸多天然产物分子和合成化合物都含有氮杂环结构并具有潜在的药物活性。采用微波照射的方法高效构筑含氮的五元、六元、多元环化合物是绿色合成杂环类化合物的重要途径，也是当今有机合成化学领域研究的热点。本文以微波合成为主旨，综述了烯胺酮(酯)为合成砌块高效构筑含氮杂环化合物的研究进展。 Nitrogen-containing heterocyclic structures often are ubiquitous scaffolds in many natural products and usually exhibit diverse biological activities. Microwave irradiation synthesis has been recognized as an important method for the environmentally-friendly preparations of novel heter-ocyclic compounds, and attracted the interest of some scientific researchers. In this review, the recent progress of microwave irradiation construction of heterocyclic compounds with enaminone or enamino ester is summarized, and a full vision of its development is made.
烯胺酮(酯)，微波合成，含氮杂环，绿色高效, Enaminone
Enamino Ester
Microwave Irradiation
N-Heterocyclic Compound
Green and Efficient
微波辅助以烯胺酮(酯)为砌块高效构筑含氮杂环化合物的研究进展<sup> </sup>
Eman M. H.等 [
42
] 报道了微波辅助下通过两条途径高效的合成含氮稠杂环化合物33 (图10)，该反应以极性溶剂AcOH作溶剂，烯胺酮砌块28和杂环化合物29反应一步成环得到目标化合物33。在此基础上，研究者发现烯胺酮砌块28可由化合物31和DMF-DMA合成，于是设计了三组分的连级反应，在微波条件下三组分化合物迅速反应生成目标化合物。新设计三组分连级反应可以减少反应步骤，提高原子利用率，并且使得原本复杂的原料变为普通简单易得原料，降低了合成反应成本。
白海瑞,王晓晶,付黄梅,王 平,黄 超. 微波辅助以烯胺酮(酯)为砌块高效构筑含氮杂环化合物的研究进展 Advances in the Study of Microwave Irradiation Efficient Construction of Heterocyclic Compounds with Enaminone or Enamino Ester as Building Blocks[J]. 有机化学研究, 2017, 05(04): 164-174. http://dx.doi.org/10.12677/JOCR.2017.54022
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