|
||||||
Entry |
Br2(eq.) |
H2O (eq.) |
m (Br2-H2O)/mg |
solvent |
Yield/2a%b |
Yield/3a%b |
1 |
1 |
46.7 |
100 |
1,4-dioxane |
58 |
5 |
2 |
1 |
46.7 |
100 |
THF |
52 |
0 |
3 |
1 |
46.7 |
100 |
EtOAc |
30 |
16 |
4 |
1 |
46.7 |
100 |
EtOH |
39 |
29 |
5 |
1 |
46.7 |
100 |
MeCN |
0 |
0 |
6 |
0.05 |
2.3 |
5 |
1,4-dioxane |
30 |
0 |
7 |
0.1 |
4.6 |
10 |
1,4-dioxane |
29 |
0 |
8 |
0.2 |
9.3 |
20 |
1,4-dioxane |
86 |
0 |
9 |
0.3 |
14 |
30 |
1,4-dioxane |
85 |
0 |
10 |
0.4 |
18.7 |
40 |
1,4-dioxane |
68 |
0 |
11 |
0.6 |
28 |
60 |
1,4-dioxane |
59 |
0 |
12 |
0.8 |
37.3 |
80 |
1,4-dioxane |
58 |
0 |
13c |
0.2 |
9.3 |
20 |
1,4-dioxane |
73 |
0 |
14d |
0.2 |
9.3 |
20 |
1,4-dioxane |
28 |
58 |
