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y |cu򗢼b2:,mx>1;vUˡfscQč/ޔ\WK,,wm2MA4F8#4% J*fDM ť F*hIEL endstream endobj 26 0 obj <>stream H\Pj w9P(a:e >h0z 1}0^P8sl1h5j'똨XnzVq2ےpY rIqEѺ v_~_C] #f^lov ϟs uZF{KPr^h$Cg5[ŬGRWU#dF1#qy\C9əukԵ짔 @|دu' endstream endobj 27 0 obj <>stream hWmo6 +bw@_kv k $vIKi V6ERQ,b 8f2$NØ3 ?֢L(6F2sp6I[@?}Nuu6}v?]M6ߺvrZs1f][Oeǔ0Y~UvLKH:B}['צHdZTjqoָwJbP g#CL 2ŋ~|ꙵ.M©Veq R'' kY&sS͟z|pZ.ﻺ<tp!** -IwU}ie ݐj0}}(MzG1r``qI90՚}blFX1d dpp*ͫrav]={>8!ljX=C2˳5$p`qm<*WYX';}/!`_ZdT|65V9EK@ Ĉr켐bDF<(;3p/7l4fGos9?ENsp -PYQMyKBk:椌B1KmHk|x';ԃEu9&r5˜ֆ(A>#(&24&tƗfsc>0"'7|py Bg&:*h6mBz1;sևZؾsݥǺcü")xfuS4f \l҄2٬54o6;َ^n/zエ(V--18VEҾx򡝈OC;y$C(\$g"#+mJd zv?Ԃ>=|P p|<☧>>stream hބVϋE.I=AHrN* uMT;35fvg%C4ċ׀ x7{fzz0]UӯW{5D`"$10jL Fb"$%x܍~WovOANR?\xrQ/V endstream endobj 29 0 obj <>stream 2024-02-03T19:43:29+08:00 2024-02-03T19:43:25+08:00 2024-02-03T19:43:29+08:00 Acrobat PDFMaker 11 Word 版 uuid:c9f38c84-babc-4d5d-a7ef-62937889092e uuid:c15e1426-fdd1-4527-97bb-d92155e3b689 12 application/pdf lnc RNA BANCR表达与TSHR甲基化在BRAFV600E突变的甲状腺乳头状癌中的研究 目的:探讨长链非编码RNA BANCR表达及TSHR甲基化与BRAFV600E突变的甲状腺乳头状癌的关系。方法:收集60例BRAFV600E突变的甲状腺乳头状癌(PTC)患者癌组织样本60例和癌旁正常甲状腺组织样本60例(简称癌旁组织),上述所有PTC患者已采用荧光定量PCR (QPCR)检测分析上述各样本BANCR基因的表达水平,并应用甲基化特异性聚合酶链反应(Methylation-Specific Polymerase chain reaction, MSP)法检测上述各样本中TSHR基因启动子甲基化情况,并分析上述癌组织和癌旁组织中各样本基因表达水平和TSHR甲基化情况与BRAFV600E突变的PTC患者的临床病理特征之间的关系。结果:癌组织组:BANCR相对表达量为(1.55 ± 1.62),高表达率为66.67%,癌旁组织组分别为(0.74 ± 0.63和30%),癌组织显著高于癌旁组织(P < 0.05)。癌组织中,BANCR高表达与肿瘤的颈部淋巴结转移存在显著相关性(P < 0.05)。癌组织组中TSHR甲基化的发生率为93.3% (56/60),癌旁组织组中TSHR甲基化的发生率为18.3% (11/60),TSHR甲基化PTC患者例数显著高于非甲基化PTC患者,差异均具有统计学意义(P均 < 0.01)。癌组织中BANCR的表达水平及TSHR甲基化以及两者联合检测阳性例数均显著高于癌旁组织,差异具有统计学差异(P均 < 0.05),BANCR高表达联合TSHR甲基化对BRAFV600E突变的PTC诊断的灵敏度、特异性和准确性较单项检测均出现上升趋势,但仅灵敏度与单一检测相比差异具有统计学意义(P < 0.05)。结论:BANCR高表达和TSHR甲基化均与BRAFV600E突变的PTC患者颈部淋巴结转移密切相关,与肿瘤的进展相关并提示不良预后。且BANCR高表达联合TSHR甲基化对BRAFV600E突变的PTC临床诊断具有较佳的灵敏度。 于波,徐宁,杨博,孙玺媛,姚佳兴,樊伟业,李松埔,窦福林,李扬 Adobe PDF Library 11.0 BANCR高表达,TSHR甲基化,基因突变,BRAFV600E突变 D:20240203114306 Microsoft çł®çı—ï¼ıæ”¢è®¨éŁ¿éfi¾éšžç¼Œç€†RNA BANCR表达å‘−TSHRçfl²å�ºå„Œä¸”BRAFV600E窆呟çı—çfl²ç−¶è–ºä¹³å¤´ç−¶çŽ„çı—å–³ç³»ã•‡æŒ¹æ³Łï¼ıæfl¶éłƒ60侉BRAFV600E窆呟çı—çfl²ç−¶è–ºä¹³å¤´ç−¶çŽ„(PTC)懣蕖玄绗ç»⁄怷本60侉噄玄抆æ�£å¸¸çfl²ç−¶è–ºç»—ç»⁄怷本60侉(箕称玄抆绗ç»⁄)$ä¸−述曕望PTC懣蕖已é⁄⁄çfl¨è“§å–›å®ıé⁄‘PCR (QPCR)棕浉勃枒ä¸−述咗怷本BANCRå�ºåł€çı—表达水平$并åºflçfl¨çfl²å�ºå„Œç›¹å¼‡æ•§è†ıå’‹é–¶éfi¾å‘“åºfl(Methylation-Specific Polymerase chain reaction, MSP)æ³Łæ£•æµ‰ä¸−述咗怷本ä¸�TSHRå�ºåł€å’¯å−¨å�’çfl²å�ºå„Œæ…–僵$并勃枒ä¸−述玄绗ç»⁄噄玄抆绗ç»⁄ä¸�咗怷本å�ºåł€è¡¨è¾¾æ°´å¹³å™„TSHRçfl²å�ºå„Œæ…–僵且BRAFV600E窆呟çı—PTC懣蕖çı—临åº−犖璃盹徆义銴çı—喳系㕇ç»fiæžœï¼ı玄绗ç»⁄ç»—ï¼ıBANCRçł¸å¯¹è¡¨è¾¾é⁄‘为(1.55 ± 1.62)$髟表达ç”⁄为66.67%$玄抆绗ç»⁄绗勃勫为(0.74 ± 0.63噄30%)$玄绗ç»⁄柾肊髟五玄抆绗ç»⁄(P < 0.05)㕇玄绗ç»⁄ä¸�$BANCR髟表达且臿矤çı—颋酨淉巴ç»fi转移å�Ÿåœ¨æŸ¾è‚Šçł¸å–³æ•§(P < 0.05)㕇玄绗ç»⁄ç»—ä¸�TSHRçfl²å�ºå„Œçı—å‘‚çfl�ç”⁄为93.3% (56/60)$玄抆绗ç»⁄ç»—ä¸�TSHRçfl²å�ºå„Œçı—å‘‚çfl�ç”⁄为18.3% (11/60)$TSHRçfl²å�ºå„ŒPTCæ‡£è•–ä¾‰æŁ°æŸ¾è‚Šé«Ÿäº”éšžçfl²å�ºå„ŒPTC懣蕖$差弇åš⁄喷望ç»�计å�¦æ—‘ä¹›(Påš⁄ < 0.01)㕇玄绗ç»⁄ä¸�BANCRçı—表达水平å‘−TSHRçfl²å�ºå„Œä»¥å‘−两蕖è†flå’‹æ£•æµ‰éŸ³æ•§ä¾‰æŁ°åš⁄柾肊髟五玄抆绗ç»⁄$差弇喷望ç»�计å�¦å·®å¼‡(Påš⁄ < 0.05)$BANCR髟表达è†flå’‹TSHRçfl²å�ºå„Œå¯¹BRAFV600E窆呟çı—PTCè¯−æŒ�çı—ç†µæŁ‘åº¦ã•†ç›¹å¼‡æ•§å™„å⁄ƒç¡®æ•§è¾…å“Łé¡¹æ£•æµ‰åš⁄å⁄ºç”°ä¸−å“⁄趉å−¿ï¼„ä½ƒä»–ç†µæŁ‘åº¦ä¸”å“Łä¸•æ£•æµ‰çł¸æ¯fl差弇喷望ç»�计å�¦æ—‘ä¹›(P < 0.05)㕇ç»fi论ï¼ıBANCR髟表达噄TSHRçfl²å�ºå„Œåš⁄且BRAFV600E窆呟çı—PTC懣蕖颋酨淉巴ç»fi转移寃å‹⁄çł¸å–³ï¼„ä¸”è‡¿çŸ¤çı—è¿łå±Łçł¸å–³å¹¶æ‘’ç¤ºä¸“è›¯é¢—å’”ã•‡ä¸flBANCR髟表达è†flå’‹TSHRçfl²å�ºå„Œå¯¹BRAFV600E窆呟çı—PTC临åº−è¯−æŒ�喷望辅佳çı—ç†µæŁ‘åº¦ã•‡ endstream endobj 30 0 obj <>stream h2P0Pw/+Q0L)620)I 14P`DT$! endstream endobj 31 0 obj <>stream hޤU]H[g*kݔ^xsQIB9:mQLs;&1GINi5 V(l+j1a ]l *eZΉqY!|~ @7tX0Vsji>ǴF_R9nB"PPȁzP/B#3<4򀏈ˆ/M| %p 0\7o .!WeO+g36X. x+1CA!\o{C©/B=@,(4m671F+8>dYpH$9>yޭK{˾맧- "ݬ s)xvK6< SoAF'{\ȬeE[#5<?i*pl9q!P(% σoGN"#vG)0q^.>2ѝg~7揄,709')O-+1=VgG'=GAJ(Jn1hj$O%q6'&& iD=gh=TB9{ָXJNv\5a_e\3yÍ9/=_C+Z>J'k!C֋nlE>Uؙ5hy]|;Hͨ 5Cl`J_ <Њj_Ifj]4ZèVfOc3ޕn"J)pFFƍW\ .P>+Vn,5V!~}fJ5,\α?Ψbہsn!&}*aFm1ȭWƨ\.=OgwتPj<}kyo˪NO_RsE4_d7}4m_OxKcQȺfM/_M 971*p;7~}aZIƐ]K8B{vױC'ygI%R Jf+h*eVuMҨp+ -)݁9a%cjDrOD9TJh%<#ehvOnsӧfdcW? 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